منابع مشابه
Binding of salivary agglutinin to IgA.
SAG (salivary agglutinin), which is identical to gp-340 (glycoprotein-340) from the lung, is encoded by DMBT1 (deleted in malignant brain tumours 1). It is a member of the SRCR (scavenger receptor cysteine-rich) superfamily and contains 14 SRCR domains, 13 of which are highly similar. SAG in saliva is partially complexed with IgA, which may be necessary for bacterial binding. The goal of the pr...
متن کاملIdentification of the hydroxyapatite-binding domain of salivary agglutinin.
The salivary agglutinin glycoprotein (SAG) is present in saliva but is also part of the salivary pellicle, playing a seemingly paradoxical role with regard to bacterial homeostasis. On the one hand, SAG aggregates bacteria in solution, thereby preventing bacterial colonization. On the other hand, when bound to the tooth surface, SAG facilitates bacterial colonization and microbial growth. The p...
متن کاملStructural basis of multivalent binding to wheat germ agglutinin.
The inhibition of carbohydrate-protein interactions by tailored multivalent ligands is a powerful strategy for the treatment of many human diseases. Crucial for the success of this approach is an understanding of the molecular mechanisms as to how a binding enhancement of a multivalent ligand is achieved. We have synthesized a series of multivalent N-acetylglucosamine (GlcNAc) derivatives and s...
متن کاملEvaluation of Salivary IgA in Diabetic and Non-Diabetic Patients: A Case-Control Study
Objective: Diabetes Mellitus as the most common metabolic disease of human has wide range of oral consequences such as oral infections which could make changes in the properties of saliva. The purpose of this study was to compare the amount of salivary IgA in diabetic and non-diabetic patients. Materials and Methods: In this case-control study, the population consisted of 40 persons including ...
متن کاملComparison of Salivary Secretory IgA in Caries-free Children and Children with Severe Early Childhood Caries
Background & Aims: Sever early childhood caries (SECC) is a multifactor common disease that unfortunately there have been a lot of unknown points about it. This study was performed to compare the levels of total S-IgA in children with and without SECC. Methods: In this cross-sectional study 44 children aged 6-24 months were divided into two groups of with SECC (n=20) and without SECC (n=24). Th...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2004
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20040265